Archives: Research Papers

EXCEL-Punjabi: the process of using a community based participatory research approach for a culturally-tailored exercise oncology intervention.

BACKGROUND: Physical activity is an effective evidence-based intervention with extensive physical and psychosocial benefits for individuals living with and beyond cancer. Despite being the largest visible minority group in Canada, uptake of currently available exercise interventions, such as the Canada-wide Exercise for Cancer to Enhance Living Well (EXCEL) study, is low among individuals of South Asian heritage living with and …

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Effects of Exercise-Based Interventions on Depressive Symptoms in Adults with Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

: Exercise is increasingly used in supportive care for lung cancer, but its effects on depressive symptoms remain uncertain. This systematic review and meta-analysis synthesized randomized evidence. : Four electronic databases were searched for reports published from January 2000 to July 2026. Eligible studies enrolled adults with lung cancer and compared a structured exercise-based intervention with usual care or an …

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Fear of Cancer Progression as a Psychological Component of Cancer Rehabilitation in Men Treated for Reproductive System Malignancies: A Multi-Regional Cross-Sectional Study in Kazakhstan.

Fear of cancer progression (FoP) is a well-recognised, clinically significant dimension of quality of life in oncology, yet it remains largely unstudied among men treated for reproductive system malignancies in Central Asia. This study assessed the level and correlates of FoP among such patients across several regions of Kazakhstan, as part of a broader research programme aimed at improving rehabilitation …

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Real-World Analysis of Olanzapine and Functional Outcomes in Outpatient Cancer Rehabilitation.

: Cachexia is a multifactorial muscle wasting syndrome driven by inflammation, causing increased catabolism and decreased food intake. Using appetite stimulation as part of multidisciplinary rehabilitation for cachexia is an emerging strategy. Olanzapine was originally developed as an atypical antipsychotic and has since emerged in rehabilitative strategies in patients with brain injury and chemotherapy-induced nausea. In 2023, the American Society …

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Exploring the feasibility of exercise training during (neo)adjuvant chemotherapy in women with early-stage breast cancer: a pilot study examining immune and metabolic outcomes.

PURPOSE: To examine the feasibility and exploratory immunological, metabolic, and patient-reported effects of a supervised exercise intervention during (neo)adjuvant chemotherapy in women with early-stage breast cancer. METHODS: This non-randomised pilot study examined a 12-week supervised combined aerobic and resistance exercise programme during (neo)adjuvant treatment. Participants self-selected into the exercise intervention, and as no eligible participants opted for the control group, …

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Patient Perspectives on Prostate Cancer Prehabilitation: A Qualitative Study Using the Behaviour Change Wheel to Investigate Barriers and Facilitators to Engagement.

Cancer prehabilitation aims to improve outcomes by helping patients physically and mentally prepare for treatment. This qualitative study aimed to investigate barriers and facilitators to engaging in prostate cancer prehabilitation and create recommendations for designing interventions. Semi-structured interviews were used to explore perspectives on cancer prehabilitation among men diagnosed with prostate cancer in Alberta, Canada. Interviews were thematically analyzed to …

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Exercise and Childhood Cancer: From Science to Life “The 3rd Pediatric Exercise Oncology Congress Meets FORTEe”.

On behalf of the organizing committee, we are pleased to present the abstracts from the 2026 conference, “PEOC meets FORTEe”. The Third Pediatric Exercise Oncology Congress, this year meeting in person with the EU Study FORTEe (Get Strong to Fight Childhood Cancer: An Exercise Intervention for Children and Adolescents Undergoing Anti-Cancer Treatment), brought together scientists, clinicians, exercise professionals, physiotherapists, patients, …

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A multidisciplinary intervention to support return to work of individuals with breast cancer: a prospective feasibility study.

PURPOSE: Work participation is one of the aims of cancer rehabilitation for individuals with breast cancer (BC). This study aimed to verify the feasibility of a multidisciplinary intervention addressing the work-related difficulties of working-age individuals with BC. METHODS: In this prospective feasibility study, employed individuals with BC who reported work-related difficulties were eligible. Participants were assessed at baseline (T0), 1 …

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Exercise as a Disease-Modifying Therapy in Colon Cancer: Practice-Changing Evidence from the CHALLENGE Trial.

Although robust observational data have long associated physical activity with improved colon cancer survival, the lack of randomized evidence has perpetuated a “causality gap,” confining exercise to supportive lifestyle advice and creating a clinical dilemma for surgeons. This paradigm has been fundamentally reshaped by the landmark phase III CHALLENGE trial. This review synthesizes the clinical, epidemiological, and translational evidence establishing …

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Exercise-Induced Skeletal Muscle Secretory Factors and Macrophage Functional Remodeling: Mechanistic Advances.

Regular exercise mediates inter-tissue communication between skeletal muscle and the immune system through skeletal muscle-derived secretory factors, providing an important molecular basis for the beneficial effects of exercise on chronic inflammation, metabolic dysregulation, and impaired tissue repair. As key effector cells of the innate immune system, macrophages do not simply conform to a dichotomous classification of classically activated M1 macrophages …

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