Archives: Research Papers

Effect of falls prevention interventions on falls and the risk factors for falls among cancer survivors: protocol for a systematic review

Introduction Falls are a significant health concern and associated with cancer survivorship. Falls can result in negative psychosocial consequences for cancer survivors and economic sequelae for healthcare delivery. There are cancer-specific fall risk factors relevant to cancer survivors which can contribute to increased fall risk. However, fall prevention may not be addressed in standard care for cancer survivors. This review …

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A Cancer Exercise Toolkit Developed Using Co-Design: Mixed Methods Study

BackgroundAccess to exercise therapy for cancer survivors is poor. Professional development to support exercise professionals in delivering these interventions is needed. Few online resources exist for exercise professionals to address this issue. ObjectiveTo develop and evaluate a freely available online toolkit to support exercise professionals working with cancer survivors. MethodsA 2-phase, experience-based co-design approach was used to develop and evaluate …

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Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy

The primary factors that can be modified in one’s lifestyle are the most influential determinants and significant preventable causes of various types of cancer. Exercise has demonstrated numerous advantages in preventing cancer and aiding in its treatment. However, the precise mechanisms behind these effects are still not fully understood. To contribute to our comprehension of exercise’s impact on cancer immunotherapy …

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SafeFit Trial: virtual clinics to deliver a multimodal intervention to improve psychological and physical well-being in people with cancer. Protocol of a COVID-19 targeted non-randomised phase III trial

Introduction The impact of the COVID-19 pandemic (caused by the SARS-CoV-2 virus) on individuals with cancer has been profound. It has led to increased anxiety, distress and deconditioning due to reduced physical activity. We aim to investigate whether SafeFit, a multimodal intervention of physical activity, nutrition and psychological support delivered virtually by cancer exercise specialists (CES), can improve physical and …

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Is physical activity related to renal cell carcinoma? A systematic review

Introduction: Relationship between renal cell carcinoma and physical activity is not clear. Objectives: This study aimed to review the relationship between renal cell carcinoma and physical activity. Methods: We searched valid databases such as PubMed/Medline, Web of Science and Scopus for search of English papers by 30/12/2018. Eleven articles were selected for final assessment. We used Kidney cancer, Exercise, Kidney …

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The Prostate cancer–Exercise and Metformin randomised controlled feasibility Trial (Pre-EMpT) in men following active surveillance, radical prostatectomy and radiotherapy

Abstract Background Moderate to vigorous physical activity and metformin are associated in epidemiological studies with reduced biochemical recurrence and mortality in men with prostate cancer. This study assessed the feasibility of a home-based physical activity and/or metformin intervention in men with non-metastatic prostate cancer following radical treatment (surgery or radiotherapy) or active surveillance. Methods A 2 × 2 factorial design randomised men …

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Effects of exercise therapy in patients with pancreatic cancer: A systematic review and meta-analysis

Introduction: The reported benefits of exercise therapy in patients with pancreatic cancer include maintaining and improving physical fitness and muscle strength, reducing treatment-related side effects, and enhancing quality of life. However, the evidence remains inconclusive, necessitating the integration of interventional studies to reach a consensus. This study aimed to elucidate the effects of exercise interventions for patients with pancreatic cancer …

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Rehabilitación temprana en cáncer: propuesta de un modelo interdisciplinario basado en vigilancia prospectiva y navegación clínica

Resumen: Las personas con diagnóstico de cáncer presentan limitaciones en las actividades de la vida diaria y en sus roles habituales como consecuencia de los efectos secundarios de la enfermedad y sus tratamientos, los cuales pueden aparecer desde etapas tempranas y persistir a largo plazo. A pesar de ello, la derivación a rehabilitación continúa siendo tardía y predominantemente reactiva. Entre …

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Re-examining content validity of the BREAST-Q more than a decade later to determine relevance and comprehensiveness

Abstract Purpose The BREAST-Q is the most used patient-reported outcome measure (PROM) in breast cancer surgery. The purposes of this study were to re-examine the content validity of BREAST-Q cancer modules (mastectomy, lumpectomy and reconstruction) and to determine the need for new scales. Methods Interviews were conducted with women with breast cancer (Stage 0–4, any treatment), and were audio-recorded and …

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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may reduce the risk of developing cancer-related lymphedema following axillary lymph node dissection (ALND)

PurposePatients undergoing axillary lymph node dissection (ALND) for breast cancer face a high risk of lymphedema, further increased by high body mass index (BMI) and insulin resistance. GLP-1 receptor agonists (GLP-1RAs) have the potential to reduce these risk factors, but their role in lymphedema has never been investigated. The purpose of this study was to determine if GLP-RAs can reduce …

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