Archives: Research Papers

Feasibility of Neuromuscular Electrical Stimulation in a Young Patient With Hematological Malignancy Unable to Perform Active Exercise: A Case Report.

Patients with hematological malignancies often have difficulty performing aerobic and resistance exercises because of the disease and the adverse effects from chemotherapy. Neuromuscular electrical stimulation (NMES) may provide an alternative rehabilitation option for patients with cancer who cannot perform conventional exercise therapy. However, the safety and feasibility of NMES in patients with severe thrombocytopenia remain unclear. This case report describes …

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Referral to cancer rehabilitation in the cancer care continuum: barriers, inequities, and opportunities for integration-a scoping review.

BACKGROUND: Functional impairments among people living with and beyond cancer can affect treatment tolerance, daily functioning, participation, and quality of life. Despite the potential benefits of rehabilitation, referral remains inconsistent. Referral barriers may also arise within related supportive-care pathways, particularly palliative care, although the purposes and indications of these services differ. OBJECTIVE: This scoping review aimed to synthesize evidence on …

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Chemotherapy-Induced Skeletal Muscle Dysfunction and Cognitive Impairment: A Muscle-Brain Mechanistic Framework With Implications for Exercise Oncology.

Chemotherapy commonly induces skeletal muscle dysfunction and cognitive impairment, complications that reduce treatment tolerance and quality of life. Skeletal muscle mass frequently declines during chemotherapy, with cohort studies reporting losses of 3%-10% across treatment courses, while chemotherapy-induced cognitive impairment affects up to one-third of patients. Emerging evidence indicates that chemotherapeutic agents impair mitochondrial function in peripheral tissues, including skeletal muscle, …

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Clinical Practice Guideline for Rehabilitation Nutrition 2026: Executive Summary of the Japanese Association of Rehabilitation Nutrition Guideline 2026-A Secondary Publication.

The Japanese Association of Rehabilitation Nutrition (JARN) published its first Japanese-language clinical practice guideline on rehabilitation nutrition in 2018, followed by an English-language 2020 update covering cerebrovascular disease, hip fracture, cancer, and acute illness. The JARN Clinical Practice Guideline 2026 (JARN GL 2026) expands the framework to 11 domains and incorporates updated evidence on malnutrition diagnosis using the Global Leadership …

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Effectiveness of exergaming interventions for adults with cancer: a systematic review.

BACKGROUND: Exergaming, which integrates physical exercise with interactive digital games, has gained attention as a supportive approach in cancer rehabilitation. However, uncertainty remains regarding its effects across different phases of cancer care and its feasibility in clinical and home-based settings. This systematic review synthesized evidence on the feasibility, safety, and effects of exergaming interventions among adults with cancer, with particular …

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Effect of Branched-Chain Amino Acid-enriched nutritional supplement after exercise on skeletal muscle mass in patients undergoing surgery for gastrointestinal cancer.

OBJECTIVES: To investigate the effects of branched-chain amino acid (BCAA)-enriched nutritional supplementation after exercise on skeletal muscle and walking ability in patients undergoing gastrointestinal cancer surgery. METHODS: Fifty patients with gastric or colorectal cancer scheduled for surgery were enrolled in this single-center, single-blind, randomized controlled study. Patients were randomly assigned to a BCAA-enriched jelly group (test group) or an amino …

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Overview of Cancer Rehabilitation Provided in Palliative Care Units in Japan: A Nationwide Survey.

OBJECTIVES: We aimed to clarify the current state of cancer rehabilitation in palliative care units (PCUs) in Japan, thus helping to improve cancer rehabilitation and effectively address patients’ complex needs. METHODS: A nationwide questionnaire survey was conducted, targeting 462 hospitals in Japan that met the eligibility criteria for reimbursement of inpatient fees for PCUs and had submitted notifications to local …

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Cost-effectiveness of a web-based peer-delivered physical activity program for breast cancer survivors.

BACKGROUND: Breast cancer survivors are increasing in number and living longer but often experience reduced quality of life (QOL) from treatment sequelae. Physical activity (PA) interventions can improve QOL, but many rely on costly specialists or are difficult to scale. We adapted an evidence-based peer-mentoring program (moving forward together) for web delivery (webMFT). The platform centralizes peer-coach matching, delivery, and …

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Association Between Danish Guideline Treatments for Breast Cancer and Physiotherapy-Relevant Late Effects: A Nationwide Cohort Study.

BACKGROUND: Breast cancer survival has improved substantially, yet many women continue to experience late effects that may require physiotherapy. Shoulder impairment, lymphedema, and fatigue are among the most common physiotherapy-relevant late effects following primary breast cancer treatment. Understanding how guideline treatments for breast cancer influence these impairments is essential for the early identification of high-risk patients and the development of …

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Therapeutic Exercise Protocol During Hospitalization in Pediatric Oncohematological Patients: Randomized Clinical Trial.

BACKGROUND: Leukemias, lymphomas, and central nervous system tumors are among the most common pediatric cancers and may lead to motor deficits, impaired balance, reduced muscle strength, fatigue, and decreased functional capacity. Early physiotherapy during hospitalization may help prevent inactivity and support functional preservation in this population. OBJECTIVE: To evaluate the effects of a therapeutic exercise program on quality of life, …

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