Archives: Research Papers

Exercise During Active Surveillance for Localized Low-Risk Prostate Cancer: Current Evidence and a Survivorship Framework.

BACKGROUND: Active Surveillance (AS) is an established management strategy for appropriately selected men with localized low-risk prostate cancer, allowing many to defer or avoid definitive treatment while remaining under structured oncologic monitoring. Because surveillance may continue for years, survivorship needs during this period warrant greater attention. OBJECTIVE: This narrative and conceptual review summarizes current evidence regarding structured exercise during AS …

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A Remotely Delivered Exercise-Based Rehabilitation Program for Patients with Persistent Chemotherapy-Induced Peripheral Neuropathy (EX-CIPN): A Phase I Feasibility Trial.

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) affects two-thirds of patients who receive neurotoxic chemotherapy. In almost half of these patients, CIPN is persistent, with limited treatment options. Exercise-based rehabilitation shows promising results in improving CIPN-related outcomes, but high-quality research is needed with CIPN symptoms and disability as primary endpoints. METHODS: We conducted a phase I single-arm, multi-method pilot study of a …

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Optimizing exercise regimens for quality of life in patients with cancer: a network meta-analysis and dose-response study.

OBJECTIVE: To systematically evaluate the effects and dose-response relationships of different exercise interventions in improving the quality of life of patients with cancer using a combined Bayesian network meta-analysis and network dose-response meta-analysis approach. METHODS: Systematic searches were conducted in PubMed, Web of Science, Embase, and the Cochrane Library (up to August 2026). Interventions were ranked using the surface under …

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Effects of sensorimotor training on chemotherapy-induced peripheral neuropathy-related outcomes in adults with cancer: A systematic review and meta-analysis of randomized controlled trials.

OBJECTIVE: To evaluate the effects of sensorimotor training (SMT)-based interventions on chemotherapy-induced peripheral neuropathy (CIPN) and related outcomes in adults with cancer. METHODS: Eleven bibliographic databases and two trial registries were searched from inception to 30 March 2026. Risk of bias was assessed for each outcome using RoB 2, and certainty of evidence was evaluated using GRADE. Meta-analyses used a …

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Psychological determinants of pain, fatigue, and symptom burden in breast cancer survivorship

Breast cancer survivors frequently experience persistent pain, cancer-related fatigue, and interconnected symptom clusters that impair quality of life, functional status, and treatment adherence. Psychological factors, including pain catastrophizing, anxiety, depression, fear-avoidance behaviors, and maladaptive cognitive appraisals, are associated with the amplification and maintenance of these symptoms through proposed mechanisms involving central sensitization, HPA axis dysregulation, inflammatory signaling, and behavioral deconditioning. …

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Feasibility of High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumor and Young Adults With Isocitrate Dehydrogenase-Mutant Gliomas (HYPE): Protocol for a Randomized Controlled Trial.

BACKGROUND: Young adult survivors of pediatric brain tumors and young adult patients with isocitrate dehydrogenase (IDH) mutant gliomas are at risk for cognitive impairment, reduced physical fitness and function, as well as poor health-related quality of life (HRQOL) and psychosocial health. Exercise improves these outcomes; however, both populations remain understudied with respect to exercise interventions. High-intensity interval training (HIIT) is …

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Perspective of Indian parents on physiotherapy rehabilitation in pediatric oncology: a qualitative phenomenological study protocol.

BACKGROUND: Advances in pediatric oncology treatment have had a positive impact on the childhood cancer survival rates across the world. Despite this, children who are receiving treatment can experience treatment related physical impairments such as fatigue, muscle weakness, less mobility, and various day to day functional limitations, and this can quietly harm their quality of life. In this context, the …

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Exploring adapted water polo: a feasibility study on improving psychosocial recovery in women post-breast cancer treatment.

PURPOSE: This study aimed to evaluate the feasibility and acceptability of an adapted water polo programme (Aqua polo) for women following breast cancer treatment. Exploratory secondary objectives were to examine changes in cancer-related fatigue (CRF), quality of life, post-traumatic growth, physical function and participants’ psychosocial experiences. The intervention was conducted in a municipal swimming pool within a renowned local club, …

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Cross-continental generalizability of EHR foundation model: predicting length of stay in an Italian hospital using US-trained embeddings

BackgroundClinical Foundations Models (FMs) hold the potential to exhibit generalist medical AI capabilities, and the ability to reduce the need for explicit feature engineering. However, their evaluation often relies on locally-limited datasets, raising questions regarding their generalizability across diverse global healthcare systems, populations, and clinical practices. This study assesses the cross-continental transferability of a US-trained FM, CLMBR-T-base, applied to a …

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