Archives: Research Papers

Psychological determinants of pain, fatigue, and symptom burden in breast cancer survivorship

Breast cancer survivors frequently experience persistent pain, cancer-related fatigue, and interconnected symptom clusters that impair quality of life, functional status, and treatment adherence. Psychological factors, including pain catastrophizing, anxiety, depression, fear-avoidance behaviors, and maladaptive cognitive appraisals, are associated with the amplification and maintenance of these symptoms through proposed mechanisms involving central sensitization, HPA axis dysregulation, inflammatory signaling, and behavioral deconditioning. …

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Feasibility of High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumor and Young Adults With Isocitrate Dehydrogenase-Mutant Gliomas (HYPE): Protocol for a Randomized Controlled Trial.

BACKGROUND: Young adult survivors of pediatric brain tumors and young adult patients with isocitrate dehydrogenase (IDH) mutant gliomas are at risk for cognitive impairment, reduced physical fitness and function, as well as poor health-related quality of life (HRQOL) and psychosocial health. Exercise improves these outcomes; however, both populations remain understudied with respect to exercise interventions. High-intensity interval training (HIIT) is …

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Perspective of Indian parents on physiotherapy rehabilitation in pediatric oncology: a qualitative phenomenological study protocol.

BACKGROUND: Advances in pediatric oncology treatment have had a positive impact on the childhood cancer survival rates across the world. Despite this, children who are receiving treatment can experience treatment related physical impairments such as fatigue, muscle weakness, less mobility, and various day to day functional limitations, and this can quietly harm their quality of life. In this context, the …

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Exploring adapted water polo: a feasibility study on improving psychosocial recovery in women post-breast cancer treatment.

PURPOSE: This study aimed to evaluate the feasibility and acceptability of an adapted water polo programme (Aqua polo) for women following breast cancer treatment. Exploratory secondary objectives were to examine changes in cancer-related fatigue (CRF), quality of life, post-traumatic growth, physical function and participants’ psychosocial experiences. The intervention was conducted in a municipal swimming pool within a renowned local club, …

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Cross-continental generalizability of EHR foundation model: predicting length of stay in an Italian hospital using US-trained embeddings

BackgroundClinical Foundations Models (FMs) hold the potential to exhibit generalist medical AI capabilities, and the ability to reduce the need for explicit feature engineering. However, their evaluation often relies on locally-limited datasets, raising questions regarding their generalizability across diverse global healthcare systems, populations, and clinical practices. This study assesses the cross-continental transferability of a US-trained FM, CLMBR-T-base, applied to a …

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Feasibility of Neuromuscular Electrical Stimulation in a Young Patient With Hematological Malignancy Unable to Perform Active Exercise: A Case Report.

Patients with hematological malignancies often have difficulty performing aerobic and resistance exercises because of the disease and the adverse effects from chemotherapy. Neuromuscular electrical stimulation (NMES) may provide an alternative rehabilitation option for patients with cancer who cannot perform conventional exercise therapy. However, the safety and feasibility of NMES in patients with severe thrombocytopenia remain unclear. This case report describes …

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Referral to cancer rehabilitation in the cancer care continuum: barriers, inequities, and opportunities for integration-a scoping review.

BACKGROUND: Functional impairments among people living with and beyond cancer can affect treatment tolerance, daily functioning, participation, and quality of life. Despite the potential benefits of rehabilitation, referral remains inconsistent. Referral barriers may also arise within related supportive-care pathways, particularly palliative care, although the purposes and indications of these services differ. OBJECTIVE: This scoping review aimed to synthesize evidence on …

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Chemotherapy-Induced Skeletal Muscle Dysfunction and Cognitive Impairment: A Muscle-Brain Mechanistic Framework With Implications for Exercise Oncology.

Chemotherapy commonly induces skeletal muscle dysfunction and cognitive impairment, complications that reduce treatment tolerance and quality of life. Skeletal muscle mass frequently declines during chemotherapy, with cohort studies reporting losses of 3%-10% across treatment courses, while chemotherapy-induced cognitive impairment affects up to one-third of patients. Emerging evidence indicates that chemotherapeutic agents impair mitochondrial function in peripheral tissues, including skeletal muscle, …

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Clinical Practice Guideline for Rehabilitation Nutrition 2026: Executive Summary of the Japanese Association of Rehabilitation Nutrition Guideline 2026-A Secondary Publication.

The Japanese Association of Rehabilitation Nutrition (JARN) published its first Japanese-language clinical practice guideline on rehabilitation nutrition in 2018, followed by an English-language 2020 update covering cerebrovascular disease, hip fracture, cancer, and acute illness. The JARN Clinical Practice Guideline 2026 (JARN GL 2026) expands the framework to 11 domains and incorporates updated evidence on malnutrition diagnosis using the Global Leadership …

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