Cancer Research Hub

OBJECTIVE: To evaluate the effects of sensorimotor training (SMT)-based interventions on chemotherapy-induced peripheral neuropathy (CIPN) and related outcomes in adults with cancer. METHODS: Eleven bibliographic databases and two trial registries were searched from inception to 30 March 2026. Risk of...

BACKGROUND: Rehabilitation is increasingly recognized as an essential component of oncology care, but there remains limited evidence regarding its broader impact on patient outcomes. This study examined the associations of inpatient cancer rehabilitation with survival and post-discharge healthcare utilization among...

This study aimed to investigate the dose-response relationships between exercise prescription parameters and a range of health outcomes in patients with colorectal cancer (CRC). The following PRISMA guidelines, a systematic search of five databases was conducted. The inclusion criteria were...

PURPOSE: Live-remote supervised exercise helps cancer survivors reduce the negative side effects of their treatment, and group dynamics are an integral aspect of successful rehabilitation outcomes. In this international group concept mapping study, we investigated which aspects of peer interaction...

PURPOSE: To determine whether dynamic-task rehabilitation, compared with bedside-only or no rehabilitation, is associated with longer time to loss of toilet ambulation among patients with advanced cancer in a palliative care unit (PCU). METHODS: This retrospective study included patients with...

BACKGROUND: Leukemias, lymphomas, and central nervous system tumors are among the most common pediatric cancers and may lead to motor deficits, impaired balance, reduced muscle strength, fatigue, and decreased functional capacity. Early physiotherapy during hospitalization may help prevent inactivity and...

BACKGROUND: Breast cancer survival has improved substantially, yet many women continue to experience late effects that may require physiotherapy. Shoulder impairment, lymphedema, and fatigue are among the most common physiotherapy-relevant late effects following primary breast cancer treatment. Understanding how guideline...

Chemotherapy commonly induces skeletal muscle dysfunction and cognitive impairment, complications that reduce treatment tolerance and quality of life. Skeletal muscle mass frequently declines during chemotherapy, with cohort studies reporting losses of 3%-10% across treatment courses, while chemotherapy-induced cognitive impairment affects...

BackgroundClinical Foundations Models (FMs) hold the potential to exhibit generalist medical AI capabilities, and the ability to reduce the need for explicit feature engineering. However, their evaluation often relies on locally-limited datasets, raising questions regarding their generalizability across diverse global...

BACKGROUND: Young adult survivors of pediatric brain tumors and young adult patients with isocitrate dehydrogenase (IDH) mutant gliomas are at risk for cognitive impairment, reduced physical fitness and function, as well as poor health-related quality of life (HRQOL) and psychosocial...

OBJECTIVE: To systematically evaluate the effects and dose-response relationships of different exercise interventions in improving the quality of life of patients with cancer using a combined Bayesian network meta-analysis and network dose-response meta-analysis approach. METHODS: Systematic searches were conducted in...

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) affects two-thirds of patients who receive neurotoxic chemotherapy. In almost half of these patients, CIPN is persistent, with limited treatment options. Exercise-based rehabilitation shows promising results in improving CIPN-related outcomes, but high-quality research is needed...

BACKGROUND: Active Surveillance (AS) is an established management strategy for appropriately selected men with localized low-risk prostate cancer, allowing many to defer or avoid definitive treatment while remaining under structured oncologic monitoring. Because surveillance may continue for years, survivorship needs...

Oxidative stress has been implicated in both cancer pathogenesis and treatment-related toxicity, and structured exercise has been proposed as a non-pharmacological strategy that may help modulate this redox imbalance in patients and survivors with cancer, although the consistency of this...

BACKGROUND: Due to advances in cancer diagnostics and treatments, life expectancy after cancer and the number of cancer survivors are increasing. Symptoms and late effects frequently occur in cancer survivors, with a negative impact on functioning and participation in society....

INTRODUCTION: With advances in early detection and multimodal therapy, survival after breast cancer has significantly improved. However, completion of curative treatment is not necessarily the end of patient suffering. Survivors frequently experience persistent psychological distress, social role disruption, altered body...

PURPOSE: Chronic cancer-related pain is a prevalent and often under-recognized issue among individuals living with or after cancer. Clinically useful tools are needed to classify pain severity and impact and to identify those requiring targeted support. This study applied the...

Although robust observational data have long associated physical activity with improved colon cancer survival, the lack of randomized evidence has perpetuated a “causality gap,” confining exercise to supportive lifestyle advice and creating a clinical dilemma for surgeons. This paradigm has...

PURPOSE: Work participation is one of the aims of cancer rehabilitation for individuals with breast cancer (BC). This study aimed to verify the feasibility of a multidisciplinary intervention addressing the work-related difficulties of working-age individuals with BC. METHODS: In this...

Cancer prehabilitation aims to improve outcomes by helping patients physically and mentally prepare for treatment. This qualitative study aimed to investigate barriers and facilitators to engaging in prostate cancer prehabilitation and create recommendations for designing interventions. Semi-structured interviews were used...

PURPOSE: To examine the feasibility and exploratory immunological, metabolic, and patient-reported effects of a supervised exercise intervention during (neo)adjuvant chemotherapy in women with early-stage breast cancer. METHODS: This non-randomised pilot study examined a 12-week supervised combined aerobic and resistance exercise...

: Cachexia is a multifactorial muscle wasting syndrome driven by inflammation, causing increased catabolism and decreased food intake. Using appetite stimulation as part of multidisciplinary rehabilitation for cachexia is an emerging strategy. Olanzapine was originally developed as an atypical antipsychotic...

Fear of cancer progression (FoP) is a well-recognised, clinically significant dimension of quality of life in oncology, yet it remains largely unstudied among men treated for reproductive system malignancies in Central Asia. This study assessed the level and correlates of...

: Exercise is increasingly used in supportive care for lung cancer, but its effects on depressive symptoms remain uncertain. This systematic review and meta-analysis synthesized randomized evidence. : Four electronic databases were searched for reports published from January 2000 to...

BACKGROUND: Physical activity is an effective evidence-based intervention with extensive physical and psychosocial benefits for individuals living with and beyond cancer. Despite being the largest visible minority group in Canada, uptake of currently available exercise interventions, such as the Canada-wide...

The Japanese Association of Rehabilitation Nutrition (JARN) published its first Japanese-language clinical practice guideline on rehabilitation nutrition in 2018, followed by an English-language 2020 update covering cerebrovascular disease, hip fracture, cancer, and acute illness. The JARN Clinical Practice Guideline 2026...

Patients with hematological malignancies often have difficulty performing aerobic and resistance exercises because of the disease and the adverse effects from chemotherapy. Neuromuscular electrical stimulation (NMES) may provide an alternative rehabilitation option for patients with cancer who cannot perform conventional...

BACKGROUND: Psychological prehabilitation aims to prepare patients for cancer treatment, yet psychological readiness is under-specified and distress during and after treatment is common. A patient-informed account of readiness is needed to guide readiness-focused, proactive psychological support in cancer care. AIMS:...

Regular exercise mediates inter-tissue communication between skeletal muscle and the immune system through skeletal muscle-derived secretory factors, providing an important molecular basis for the beneficial effects of exercise on chronic inflammation, metabolic dysregulation, and impaired tissue repair. As key effector...

INTRODUCTION: The rehabilitation of patients following jaw tumor resection presents significant challenges, with the goal of restoring both function and quality of life (QoL). Dental implant-supported prostheses are a cornerstone of this rehabilitation, yet the optimal protocol is not universal....