Archives: Research Papers
Graded Exercise Therapy and Cognitive Behavioral Therapy for Fatigue in Patients With Breast Cancer: Protocol for a Randomized Controlled Pilot Study.
BACKGROUND: Fatigue is a common debilitating symptom of breast cancer (BC), and its treatment may result in a significant symptom burden and affect adherence to treatment. Graded exercise therapy (GET) and cognitive behavioral therapy (CBT) have separately been shown in previous studies to be beneficial for the management of cancer-related fatigue. OBJECTIVE: This study’s coprimary aims are to assess the …
The Effect of Self-Rehabilitation on Physical Fitness in Adults with Hematological Malignancies (HMs) Undergoing Hematopoietic Stem Cell Transplantation (HSCT).
: Hematologic malignancies (HMs) represent a growing global health burden, and HSCT remains a cornerstone of treatment for many HMs. Despite improvements in survival, transplantation-related physical deconditioning is a persistent clinical challenge, and evidence supporting structured inpatient exercise interventions is scarce. To evaluate the effects of a self-directed aerobic exercise program on a cycle ergometer in inpatients under isolation precautions …
Therapeutic potential and mechanisms of rehabilitation interventions in preventing cancer metastasis.
Cancer, a significant global public health challenge, has had a persistent increase in both incidence and mortality rates, with metastasis accounting for nearly 90% of cancer-related deaths worldwide. Consequently, the efficient prevention of cancer metastasis has emerged as a vital subject in contemporary medical research and clinical practice at the global level. This narrative review summarizes preclinical and clinical evidence …
Palliative Care as an Adjunct to Standard Pulmonary Rehabilitation: A Pathway To Improving Functional Independence & Quality of Life in a Patient With Lung Cancer.
Adenocarcinoma of the lung along with malignant pleural effusion is an autonomous predictor of decreased survival, thus the main focus of the clinician should be on palliative care. In this case report, we describe chemotherapy, palliative care physiotherapy, and the necessary pulmonary rehabilitation approaches that were used for our patient. It offers a path to treatment planning, with a day-wise …
Knowledge, awareness and use of current practice of palliative care amongst physiotherapists.
BACKGROUND: Recently, there has been a marked increase in the incidence of cancer, HIV, and other noncommunicable diseases globally. Thus, the demand for palliative care (PC), including end-of-life care, continues to grow worldwide. Physiotherapy has an important role in PC as it aims to alleviate symptoms and improve quality of life by optimising independent levels of function. OBJECTIVE: To assess …
Physical activity and the Neuro-Immuno-Fascial interface in cancer patients: mechanisms, clinical evidence, and therapeutic integration.
Physical activity has progressed from supportive care to an evidence-based oncologic intervention, with large cohort studies showing dose-dependent reductions in all-cause cancer mortality of roughly 20-47% across multiple tumor entities, and randomized trial evidence supporting a pooled reduction of approximately 26%. The CCTG CO.21 CHALLENGE trial, the first randomized controlled trial powered for survival endpoints, demonstrated that structured post-adjuvant exercise …
Criterion Validity of a Consumer Wearable for Step Counting and Activity Intensity Classification in Adults With Lung Cancer: Laboratory-Based Validation Study.
BACKGROUND: Consumer wearable activity monitors are increasingly being used as end points in exercise-oncology trials and in clinical decision-making, yet their accuracy is unvalidated in lung cancer, where slow, fragmented gait may challenge step-counting algorithms. OBJECTIVE: This study assessed the criterion validity of the Fitbit Charge 6 device against video-recorded direct observation in adults with lung cancer under controlled laboratory …
Dental implant rehabilitation after jaw tumor resection: a mini-review of protocols and quality of life across treatment modalities.
INTRODUCTION: The rehabilitation of patients following jaw tumor resection presents significant challenges, with the goal of restoring both function and quality of life (QoL). Dental implant-supported prostheses are a cornerstone of this rehabilitation, yet the optimal protocol is not universal. This mini-review synthesizes recent evidence to analyze how the initial oncological treatment modality dictates the pathway, challenges, and outcomes of …
Muscle-Tumor Crosstalk in Exercise Oncology: Exercise-Induced Myokines and Cancer Cachexia.
Exercise-induced myokines, such as IL-6, irisin, and myostatin, play crucial roles in mediating systemic adaptations and modulating tumor progression. This narrative review synthesizes evidence on how regular moderate-intensity exercise affects the myokine network within the tumor microenvironment (TME) of solid tumors. Results from the 86 included studies indicate that structured training (aerobic: 45-65% VO max; resistance: 45-70% 1RM) enhances the …
