Archives: Research Papers

Combined aerobic and strength exercise training on biological ageing in Singaporean breast cancer patients: protocol for the Breast Cancer Exercise Intervention (BREXINT) Pilot Study.

Breast cancer (BC) is the most prominent cancer amongst women, but fortunately, early diagnosis and advances in multimodality treatments have improved patient survivability. Cancer survivors, however, experience increased biological ageing which may accelerate other co-morbidities. Exercise intervention is a promising clinical adjuvant approach to improve BC patients’ physiological function, recovery from treatment, and quality of life. However, the effects of …

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Visual analysis of the research frontiers, hotspots and trends of exercise therapy intervention in tumor-related sleep-wake disorders.

OBJECTIVE: To systematically understand the research frontiers, hotspots and development trends of exercise therapy in the intervention of tumor-related sleep-wake disorders, and to provide scientific basis for follow-up research. METHODS: Downloaded the original research papers on February 26, 2024, from the Web of Science core collection database, on tumor-associated sleep-wake disorders. The data that met the inclusion criteria were imported …

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Effects of exercise therapy on chemotherapy delivery and response in primary breast cancer: A secondary analysis of a randomized trial.

BACKGROUND: Whether structured exercise therapy improves chemotherapy delivery, tolerability, and tumor response is unclear. METHODS: This was a secondary analysis of a phase 2 trial investigating exercise therapy (n = 72) versus usual care (n = 72) in patients with primary breast cancer. Exercise therapy comprised individualized treadmill walking three times weekly for 20-50 minutes per session at 55%-100% of pretreatment exercise capacity. Chemotherapy …

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Graded Exercise Therapy and Cognitive Behavioral Therapy for Fatigue in Patients With Breast Cancer: Protocol for a Randomized Controlled Pilot Study.

BACKGROUND: Fatigue is a common debilitating symptom of breast cancer (BC), and its treatment may result in a significant symptom burden and affect adherence to treatment. Graded exercise therapy (GET) and cognitive behavioral therapy (CBT) have separately been shown in previous studies to be beneficial for the management of cancer-related fatigue. OBJECTIVE: This study’s coprimary aims are to assess the …

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The Effect of Self-Rehabilitation on Physical Fitness in Adults with Hematological Malignancies (HMs) Undergoing Hematopoietic Stem Cell Transplantation (HSCT).

: Hematologic malignancies (HMs) represent a growing global health burden, and HSCT remains a cornerstone of treatment for many HMs. Despite improvements in survival, transplantation-related physical deconditioning is a persistent clinical challenge, and evidence supporting structured inpatient exercise interventions is scarce. To evaluate the effects of a self-directed aerobic exercise program on a cycle ergometer in inpatients under isolation precautions …

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Therapeutic potential and mechanisms of rehabilitation interventions in preventing cancer metastasis.

Cancer, a significant global public health challenge, has had a persistent increase in both incidence and mortality rates, with metastasis accounting for nearly 90% of cancer-related deaths worldwide. Consequently, the efficient prevention of cancer metastasis has emerged as a vital subject in contemporary medical research and clinical practice at the global level. This narrative review summarizes preclinical and clinical evidence …

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Palliative Care as an Adjunct to Standard Pulmonary Rehabilitation: A Pathway To Improving Functional Independence & Quality of Life in a Patient With Lung Cancer.

Adenocarcinoma of the lung along with malignant pleural effusion is an autonomous predictor of decreased survival, thus the main focus of the clinician should be on palliative care. In this case report, we describe chemotherapy, palliative care physiotherapy, and the necessary pulmonary rehabilitation approaches that were used for our patient. It offers a path to treatment planning, with a day-wise …

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Knowledge, awareness and use of current practice of palliative care amongst physiotherapists.

BACKGROUND: Recently, there has been a marked increase in the incidence of cancer, HIV, and other noncommunicable diseases globally. Thus, the demand for palliative care (PC), including end-of-life care, continues to grow worldwide. Physiotherapy has an important role in PC as it aims to alleviate symptoms and improve quality of life by optimising independent levels of function. OBJECTIVE: To assess …

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Physical activity and the Neuro-Immuno-Fascial interface in cancer patients: mechanisms, clinical evidence, and therapeutic integration.

Physical activity has progressed from supportive care to an evidence-based oncologic intervention, with large cohort studies showing dose-dependent reductions in all-cause cancer mortality of roughly 20-47% across multiple tumor entities, and randomized trial evidence supporting a pooled reduction of approximately 26%. The CCTG CO.21 CHALLENGE trial, the first randomized controlled trial powered for survival endpoints, demonstrated that structured post-adjuvant exercise …

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