Research Topic: Lung Neoplasms

Exercise-induced metabolic reprogramming in lung cancer and its translational implications for therapeutic advancement.

Lung cancer remains one of the leading causes of cancer-related mortality worldwide, characterized by profound metabolic reprogramming that sustains malignant growth, immune evasion, and therapeutic resistance. Aberrant activation of glycolysis, increased fatty acid synthesis and uptake, and dysregulated glutamine metabolism provide energy and biosynthetic substrates while reshaping the tumor microenvironment through lactate accumulation, acidosis, and angiogenic signaling. Experimental and clinical …

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Effects of Exercise-Based Interventions on Depressive Symptoms in Adults with Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

: Exercise is increasingly used in supportive care for lung cancer, but its effects on depressive symptoms remain uncertain. This systematic review and meta-analysis synthesized randomized evidence. : Four electronic databases were searched for reports published from January 2000 to July 2026. Eligible studies enrolled adults with lung cancer and compared a structured exercise-based intervention with usual care or an …

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‘You’ve Given Me My Voice’-Enhancing Engagement in Exercise Oncology Research: A Patient and Public Involvement Approach to Co‑Designing a Pre‑Radiotherapy Exercise Programme With People Living With Lung Cancer.

BACKGROUND: Emerging evidence suggests exercise may improve radiotherapy efficacy by reducing treatment resistance caused by tumour hypoxia. However, recruitment to exercise oncology studies is low (median 38%), particularly for people with lung cancer. One strategy to address such engagement barriers is by collaborating through Patient and Public Involvement and Engagement (PPIE). OBJECTIVE: To co-design an acceptable pre‑radiotherapy exercise programme for …

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Criterion Validity of a Consumer Wearable for Step Counting and Activity Intensity Classification in Adults With Lung Cancer: Laboratory-Based Validation Study.

BACKGROUND: Consumer wearable activity monitors are increasingly being used as end points in exercise-oncology trials and in clinical decision-making, yet their accuracy is unvalidated in lung cancer, where slow, fragmented gait may challenge step-counting algorithms. OBJECTIVE: This study assessed the criterion validity of the Fitbit Charge 6 device against video-recorded direct observation in adults with lung cancer under controlled laboratory …

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