Research Topic: Humans

Dynamic task-based rehabilitation and time to loss of toilet ambulation in a palliative care unit: a retrospective cohort study.

PURPOSE: To determine whether dynamic-task rehabilitation, compared with bedside-only or no rehabilitation, is associated with longer time to loss of toilet ambulation among patients with advanced cancer in a palliative care unit (PCU). METHODS: This retrospective study included patients with cancer admitted to a PCU who died during hospitalization (January 2020-March 2024). Eligible patients had walked to an in-room fixed …

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Exploring optimal group dynamics and their feasibility during a live-remote exercise program for cancer survivors: an international concept mapping study.

PURPOSE: Live-remote supervised exercise helps cancer survivors reduce the negative side effects of their treatment, and group dynamics are an integral aspect of successful rehabilitation outcomes. In this international group concept mapping study, we investigated which aspects of peer interaction and trainer behaviour participants consider important and how feasible those preferences are according to exercise professionals. METHODS: Participants who completed …

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Exercise-induced metabolic reprogramming in lung cancer and its translational implications for therapeutic advancement.

Lung cancer remains one of the leading causes of cancer-related mortality worldwide, characterized by profound metabolic reprogramming that sustains malignant growth, immune evasion, and therapeutic resistance. Aberrant activation of glycolysis, increased fatty acid synthesis and uptake, and dysregulated glutamine metabolism provide energy and biosynthetic substrates while reshaping the tumor microenvironment through lactate accumulation, acidosis, and angiogenic signaling. Experimental and clinical …

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Optimal Exercise Dose for Improving Multidimensional Health Outcomes in Colorectal Cancer Patients: A Systematic Review, Meta-Analysis and Meta-Regression.

This study aimed to investigate the dose-response relationships between exercise prescription parameters and a range of health outcomes in patients with colorectal cancer (CRC). The following PRISMA guidelines, a systematic search of five databases was conducted. The inclusion criteria were randomized controlled trials (RCTs) of exercise interventions lasting ≥ 4 weeks in patients with CRC. Robust Variance Estimation (RVE) was used to …

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Associations of Cancer Rehabilitation During Hospitalization for Cancer Treatment With Survival and Post-Discharge Healthcare Utilization: A Multicenter Retrospective Cohort Study.

BACKGROUND: Rehabilitation is increasingly recognized as an essential component of oncology care, but there remains limited evidence regarding its broader impact on patient outcomes. This study examined the associations of inpatient cancer rehabilitation with survival and post-discharge healthcare utilization among patients with diverse cancer types. METHODS: We conducted a multicenter retrospective cohort study using cancer registry-linked claims data from designated …

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Development of CaReScreen, a Digital Health Tool for Assessing Late Effects and Cancer Rehabilitation Needs in Cancer Survivors: Protocol for a Qualitative Development and Formative Design Study.

BACKGROUND: Due to advances in cancer diagnostics and treatments, life expectancy after cancer and the number of cancer survivors are increasing. Symptoms and late effects frequently occur in cancer survivors, with a negative impact on functioning and participation in society. Digital health tools might be helpful to systematically assess symptom burden of late effects and rehabilitation needs. OBJECTIVE: This paper …

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A Remotely Delivered Exercise-Based Rehabilitation Program for Patients with Persistent Chemotherapy-Induced Peripheral Neuropathy (EX-CIPN): A Phase I Feasibility Trial.

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) affects two-thirds of patients who receive neurotoxic chemotherapy. In almost half of these patients, CIPN is persistent, with limited treatment options. Exercise-based rehabilitation shows promising results in improving CIPN-related outcomes, but high-quality research is needed with CIPN symptoms and disability as primary endpoints. METHODS: We conducted a phase I single-arm, multi-method pilot study of a …

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Exercise During Active Surveillance for Localized Low-Risk Prostate Cancer: Current Evidence and a Survivorship Framework.

BACKGROUND: Active Surveillance (AS) is an established management strategy for appropriately selected men with localized low-risk prostate cancer, allowing many to defer or avoid definitive treatment while remaining under structured oncologic monitoring. Because surveillance may continue for years, survivorship needs during this period warrant greater attention. OBJECTIVE: This narrative and conceptual review summarizes current evidence regarding structured exercise during AS …

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Optimizing exercise regimens for quality of life in patients with cancer: a network meta-analysis and dose-response study.

OBJECTIVE: To systematically evaluate the effects and dose-response relationships of different exercise interventions in improving the quality of life of patients with cancer using a combined Bayesian network meta-analysis and network dose-response meta-analysis approach. METHODS: Systematic searches were conducted in PubMed, Web of Science, Embase, and the Cochrane Library (up to August 2026). Interventions were ranked using the surface under …

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Feasibility of High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumor and Young Adults With Isocitrate Dehydrogenase-Mutant Gliomas (HYPE): Protocol for a Randomized Controlled Trial.

BACKGROUND: Young adult survivors of pediatric brain tumors and young adult patients with isocitrate dehydrogenase (IDH) mutant gliomas are at risk for cognitive impairment, reduced physical fitness and function, as well as poor health-related quality of life (HRQOL) and psychosocial health. Exercise improves these outcomes; however, both populations remain understudied with respect to exercise interventions. High-intensity interval training (HIIT) is …

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