Cancer Research Hub

BACKGROUND: Leukemias, lymphomas, and central nervous system tumors are among the most common pediatric cancers and may lead to motor deficits, impaired balance, reduced muscle strength, fatigue, and decreased functional capacity. Early physiotherapy during hospitalization may help prevent inactivity and...

BACKGROUND: Breast cancer survival has improved substantially, yet many women continue to experience late effects that may require physiotherapy. Shoulder impairment, lymphedema, and fatigue are among the most common physiotherapy-relevant late effects following primary breast cancer treatment. Understanding how guideline...

Chemotherapy commonly induces skeletal muscle dysfunction and cognitive impairment, complications that reduce treatment tolerance and quality of life. Skeletal muscle mass frequently declines during chemotherapy, with cohort studies reporting losses of 3%-10% across treatment courses, while chemotherapy-induced cognitive impairment affects...

BackgroundClinical Foundations Models (FMs) hold the potential to exhibit generalist medical AI capabilities, and the ability to reduce the need for explicit feature engineering. However, their evaluation often relies on locally-limited datasets, raising questions regarding their generalizability across diverse global...

BACKGROUND: Young adult survivors of pediatric brain tumors and young adult patients with isocitrate dehydrogenase (IDH) mutant gliomas are at risk for cognitive impairment, reduced physical fitness and function, as well as poor health-related quality of life (HRQOL) and psychosocial...

PURPOSE: Chronic cancer-related pain is a prevalent and often under-recognized issue among individuals living with or after cancer. Clinically useful tools are needed to classify pain severity and impact and to identify those requiring targeted support. This study applied the...

Although robust observational data have long associated physical activity with improved colon cancer survival, the lack of randomized evidence has perpetuated a “causality gap,” confining exercise to supportive lifestyle advice and creating a clinical dilemma for surgeons. This paradigm has...

PURPOSE: Work participation is one of the aims of cancer rehabilitation for individuals with breast cancer (BC). This study aimed to verify the feasibility of a multidisciplinary intervention addressing the work-related difficulties of working-age individuals with BC. METHODS: In this...

Cancer prehabilitation aims to improve outcomes by helping patients physically and mentally prepare for treatment. This qualitative study aimed to investigate barriers and facilitators to engaging in prostate cancer prehabilitation and create recommendations for designing interventions. Semi-structured interviews were used...

PURPOSE: To examine the feasibility and exploratory immunological, metabolic, and patient-reported effects of a supervised exercise intervention during (neo)adjuvant chemotherapy in women with early-stage breast cancer. METHODS: This non-randomised pilot study examined a 12-week supervised combined aerobic and resistance exercise...

: Cachexia is a multifactorial muscle wasting syndrome driven by inflammation, causing increased catabolism and decreased food intake. Using appetite stimulation as part of multidisciplinary rehabilitation for cachexia is an emerging strategy. Olanzapine was originally developed as an atypical antipsychotic...

Fear of cancer progression (FoP) is a well-recognised, clinically significant dimension of quality of life in oncology, yet it remains largely unstudied among men treated for reproductive system malignancies in Central Asia. This study assessed the level and correlates of...

: Exercise is increasingly used in supportive care for lung cancer, but its effects on depressive symptoms remain uncertain. This systematic review and meta-analysis synthesized randomized evidence. : Four electronic databases were searched for reports published from January 2000 to...

BACKGROUND: Physical activity is an effective evidence-based intervention with extensive physical and psychosocial benefits for individuals living with and beyond cancer. Despite being the largest visible minority group in Canada, uptake of currently available exercise interventions, such as the Canada-wide...

The Japanese Association of Rehabilitation Nutrition (JARN) published its first Japanese-language clinical practice guideline on rehabilitation nutrition in 2018, followed by an English-language 2020 update covering cerebrovascular disease, hip fracture, cancer, and acute illness. The JARN Clinical Practice Guideline 2026...

Patients with hematological malignancies often have difficulty performing aerobic and resistance exercises because of the disease and the adverse effects from chemotherapy. Neuromuscular electrical stimulation (NMES) may provide an alternative rehabilitation option for patients with cancer who cannot perform conventional...

BACKGROUND: Psychological prehabilitation aims to prepare patients for cancer treatment, yet psychological readiness is under-specified and distress during and after treatment is common. A patient-informed account of readiness is needed to guide readiness-focused, proactive psychological support in cancer care. AIMS:...

Regular exercise mediates inter-tissue communication between skeletal muscle and the immune system through skeletal muscle-derived secretory factors, providing an important molecular basis for the beneficial effects of exercise on chronic inflammation, metabolic dysregulation, and impaired tissue repair. As key effector...

INTRODUCTION: The rehabilitation of patients following jaw tumor resection presents significant challenges, with the goal of restoring both function and quality of life (QoL). Dental implant-supported prostheses are a cornerstone of this rehabilitation, yet the optimal protocol is not universal....

BACKGROUND: Consumer wearable activity monitors are increasingly being used as end points in exercise-oncology trials and in clinical decision-making, yet their accuracy is unvalidated in lung cancer, where slow, fragmented gait may challenge step-counting algorithms. OBJECTIVE: This study assessed the...

On behalf of the organizing committee, we are pleased to present the abstracts from the 2026 conference, “PEOC meets FORTEe”. The Third Pediatric Exercise Oncology Congress, this year meeting in person with the EU Study FORTEe (Get Strong to Fight...

BACKGROUND: Fatigue is a common debilitating symptom of breast cancer (BC), and its treatment may result in a significant symptom burden and affect adherence to treatment. Graded exercise therapy (GET) and cognitive behavioral therapy (CBT) have separately been shown in...

This study aims to evaluate longitudinal changes in health state utility values, health-related quality of life, physical function, nutritional status, and fatigue in patients with malignant lymphoma from the start of chemotherapy to 1 year post-chemotherapy and clarify the implications...

BACKGROUND: Emerging evidence suggests exercise may improve radiotherapy efficacy by reducing treatment resistance caused by tumour hypoxia. However, recruitment to exercise oncology studies is low (median 38%), particularly for people with lung cancer. One strategy to address such engagement barriers...

Physical exercise is a vital component of cancer rehabilitation, with demonstrated improvements in cancer health-related outcomes, relapse rates, mortality and overall survival, yet global participation remains low. In Singapore, uptake of community cancer rehabilitation is limited despite high prevalence of...

: Cardiovascular toxicity and pre-existing cardiovascular disease can affect cancer-treatment tolerance, functional recovery, and survivorship. This narrative review aimed to summarize current evidence and propose an author-derived risk-adaptive clinical framework for adult cardio-oncology rehabilitation (CORE), organized around exercise prescription, multimodal...

BACKGROUND: Mounting evidence underscores the adverse effects of excess body weight during cancer survivorship, yet many breast cancer survivors struggle to maintain a healthy weight (approximately 70% have overweight or obesity [OW/OB]). Daily caloric restriction with increased physical activity is...

As cancer survival improves, rehabilitation has become an increasingly important component of comprehensive oncology care, addressing the growing burden of treatment-related impairments. Although electrotherapy modalities are widely used in Physical and Rehabilitation Medicine, their application in oncology remains controversial because...

BACKGROUND: Immune fitness (IF) reflects the body’s ability to mount appropriate immune responses. Monitoring IF could improve tailored treatment in oncological rehabilitation. The Immune Status Questionnaire (ISQ) and the Single-Item Scale (SIS) were developed to assess IF, but their clinimetric...